PT10_OA_Harpal 1

Background: Both the Estrogen and Progesterone hormones and their receptors are thought to be involved in the process of tumor genesis in ovarian cancer. The main aim of present study was to evaluate the histopathological pattern of ovarian neoplasms and to study the expression of estrogen and progesterone status in ovarian epithelial tumours. Methods: The study was carried out on 60 cases of ovarian neoplasms. Out of all 60 cases, 46 epithelial ovarian neoplasms were studied for estrogen and progesterone expression detected through IHC and their correlation with histopathological pattern, age, menopausal status and stage of tumour was studied. Results: Among the 60 cases, 68.3% were benign, 26.7% were malignant and 5 % were borderline. Surface epithelial tumors constituted 76.66%, Germ cell tumours constituted 15.55% and sex cord stromal tumours constituted 6.66% of all tumours. Serous cystadenoma comprised of 43.33% of all cases. Serous cystadenocarcinoma and mature teratoma both constituted 13.33% of all tumours. ER and PR expression was seen in 34.28% and 31.42% of serous neoplasms respectively. Mucinous neoplasms showed 11.11% positivity for PR expression. Among serous tumours, ER and PR both showed positivity in 75% of malignant tumours and positivity of 19.2% and 19.23% for benign tumours respectively. ER and PR showed higher expression in serous tumours. ER and PR expression was more among postmenopausal females. (66.66% and 75% respectively). Both ER and PR showed higher expression in Stage III ovarian neoplasms.(66.66% and 100% respectively). Conclusion: Surface epithelial tumours were most common histopathological pattern among benign and malignant tumours. Estrogen and Progesterone showed higher expression in serous tumours and in postmenopausal patients. ER and PR expression was more in higher stage of ovarian tumours. So estimation of Estrogen and Progesterone receptors may help to select the women with ovarian malignancy for hormonal therapy.